But hopefully … after reading these risks, you’ve made the right decision. and that is to use natural alternatives to Benadryl for you dog.

Natural Alternatives To Benadryl

So … here are some conditions people use Benadryl for … and natural options you can use instead. 

Benadryl Alternatives For Allergies And Skin Problems

Allergies are complicated. If your dog has any kind of allergy issue you’ll need to figure out what’s causing the problem. Your dog may have:

  • Itchy or irritated skin
  • Hives
  • Hotspots
  • Ear infections
  • Digestive issues
  • Chronic diarrhea

It could stem from things like …

  • Food
  • Medication
  • Pest control products
  • Vaccination
  • Yeast infection
  • Seasonal allergies
  • Environmental toxins
  • Autoimmune disease

… or other causes

So … you’ll have to do some detective work. You may need a holistic vet’s help in getting to the bottom of the problem. (Hint: don’t ask a conventional vet. He’ll almost certainly prescribe suppressive drugs. These might include Benadryl, Apoquel, Cytopoint, antibiotics or steroids). 

Once you’ve nailed down the issue, you can start to make changes that’ll help. And you can try some natural supplements that help with allergies. 

Instead of those drugs, consider natural options like these. 


Colostrum is the substance in mother’s first milk that helps build the newborn’s immune system. And it can help your dog’s immune system deal with allergies. Colostrum is most effective with environmental and seasonal allergies. 

Give your dog 1/3 tsp powdered colostrum per 25 lbs of body weight, twice a day.



If you want an alternative to Benadryl, consider quercetin. In fact, quercetin is often referred to as as Nature’s Benadryl. That’s because it can stop the body from releasing histamines. 

Quercetin is naturally in foods like berries and apples (especially with the skin on). 

You can also buy a quercetin supplement at a health food store. Give your dog 80 mg of quercetin powder per 10 lbs of body weight. 

Medicinal Mushrooms

Mushrooms are another food that can help boost your dog’s immune response. That’s because of the main medicinal property, beta-glucan.

Beta-glucans change certain immune cells, helping to prevent the allergic response and inflammation. It activates other immune cells that help remove unwanted substances from the body.

The mushrooms with the highest beta-glucan content are:

If you give your dog whole mushrooms, be sure to cook them. Raw mushrooms are quite indigestible

Or buy a mushroom supplement. There are two things to look for in a mushroom supplement:

  1. Check the certificate of analysis to make sure it has at least 30% beta-glucan content. 
  2. Make sure your mushrooms are whole mushrooms, not just mycelium. Mycelium is only part of the mushroom; it’s grown on grains, making it much higher in starch. 

Follow the manufacturer’s instructions on dosing. If you use a product made for humans, assume the dose is for a 150 lb person and adjust for your dog’s weight. 

Alternatives For Bee Stings And Insect Bites

Insect bites and stings are another ailment people use Benadryl for. But there are much better options. 

Fast Remedies For Insect Stings

When I’m out in the woods with my dogs in the summer, I always carry two homeopathic remedies with me … 

  • Ledum palustre (30C or 200C): an effective remedy for most insect stings or puncture wounds.
  • Apis mellifica (30C or 200C): this remedy works well for allergic reactions. It helps with stings or red or swollen bites.

I’ve seen my dogs get stung on a few occasions. They might step on a ground hornet, or get a bee sting on the face. One of these remedies will usually bring down the pain and swelling right away. 

  • Try Apis first if the sting becomes very swollen and red, with lots of itching and even pain. 
  • Try Ledum first if the bite area is cold and puffy. 

Carry the little tubes of pellets with you. If your dog gets stung:

  • Twist the tube until 2-3 pellets fall into the cap
  • Try not to touch the pellets with your hands
  • Tip the pellets into his mouth straight out of the cap. (I like to pull out the lower lip near the corner of the mouth and put them in there.) 
  • Give 2 or 3 doses like this in the first hour.
  • You should see a very quick improvement, with reduced swelling and discomfort. 
  • If not, try the other remedy. 

Plaintain – More Than A Weed!

A great herbal remedy for insect bites is one you might find whenever you’re out walking. You may consider it a weed in your back yard … but plantain is a great way to treat insect stings in an emergency.

The juice of the plantain leaf is what you’ll need to soothe the sting. The easiest way to do that is chew it a little to release the juice, then rub the leaf on the sting. Reapply as needed. 

Natural Alternatives To Benadryl For Anxiety

Whatever causes anxiety … it may be separation anxiety or fear of thunder or fireworks

… your vet will often suggest Benadryl for your dog. Because of its sedative effects, it can help calm your dog. 

Instead, consider one of the many natural solutions for anxiety. There are many options … including herbsflower essencesessential oils, and homeopathy.

But one of the most effective remedies for your dog’s anxiety, whatever the cause … is CBD oil.  

CBD Oil For Anxiety

CBD oil comes from the hemp plant. It has similar calming effects to marijuana … but without the THC that gets people high.

And now there are studies showing CBD has anxiolytic – … or anti-anxiety effects. You can give your dog CBD oil … and the most common side effect is that he might get a little sleepy. 

Buy an organic, full spectrum CBD oil with a full range of cannabinoids: CBD, CBA, CBC, CBN and CBG. These all work together for the “entourage effect.” 

Click here to read more detail about choosing the best CBD for your dog. 

The general rule for dosing CBD is to give your dog 1mg to 6mg of CBD per 10 lbs of body weight. (You’ll need to check how much actual CBD is in each dropper of the oil you buy).

Motion Sickness

If your dog gets queasy in the car, there are lots of things to help him. Your vet might recommend Benadryl, or even Dramamine. 

But try one of these solutions instead.


Most dogs will outgrow motion sickness. So start by taking your dog for lots of short rides around the block. Or take him somewhere fun like the park. That way he should start to expect a fun time when he gets in the car … instead of worrying about a trip to the vet or groomer. Being anxious in the car will make him more likely to get carsick.


Ginger, peppermint or fennel are all good herbs for nausea. You can make a tea from one or more of these herbs. Let it cool, and give some to your dog about 30-60 minutes before getting in the car.  Give 1 Tbsp per 20 lbs of body weight. 

Flower Essences

If your dog’s nausea is due to anxiety, flower essences can help. Try giving him the combination flower essence Rescue Remedy before each trip. You can give it as often as needed. It’s calming, gentle and has no side effects.


Several homeopathic remedies can help with car sickness. Choose the one that best fits your dog and give it 30 to 60 minutes before a car ride. 

Nux vomica 30C: often used for digestive problems, Nux can also help a carsick dog. It may stop him from vomiting in the car. 

Sepia 30C: if your dog feels anxious about getting in the car, this remedy can cheer him up. It’s an especially good remedy for senior dogs.

Cocculus indicus 30C: This remedy works well for a dog who seems to get worse when you open the car window! So don’t let the fresh air in for a dog like this. 

Tabacum 30C: Use this remedy for a dog who thinks a car ride means something unpleasant … like a trip to the vet.

To give the remedy, put 2-3 pellets in a small glass of spring or filtered water. Stir it several times, then use a teaspoon or glass dropper to put some liquid on your dog’s gums. You can also make this liquid up in a glass dropper bottle and bring it with you for the ride home. 

Mast Cell Tumors

Conventional vets often give Benadryl to dogs with mast cell tumors (MCTs). Because MCTs cause excess histamine in the body … Benadryl can help control that response. But once again, that’s just a short-term solution that suppresses your dog’s natural healing.

Canine herbalist Rita Hogan recommends several herbal treatments for your dog’s MCT. These include: 

  • Ashwaganda
  • Astragalus Root
  • Burdock Root
  • Calendula or Cleavers
  • Dandelion Root and Leaf
  • Echinacea
  • Maritime Pine Bark
  • Nettles
  • Red Clover
  • Sweet Violet

Read Rita’s advice on how to use these herbs for mast cell tumors here.

Reverse Sneezing

It’s hard to describe reverse sneezing … but you might find it quite alarming to see your dog do it. It’s not really a sneeze … but more of a series of spasmodic inhalations. Your dog may make some snorting or gagging noises. He might hang his head low and look unhappy.

Conventional vets view reverse sneezing as an allergic response. They often suggest massaging your dog’s throat to help stop the spasms. They also suggest covering the nostrils to make your dog swallow. 

And they will also tell you to give your dog Benadryl, to suppress the reverse sneezing response. 

But again, Benadryl only covers up the symptoms. It doesn’t fix the problem.

Reverse sneezing is often a chronic condition … but all kinds of things can trigger it. I have a dog who reverse sneezes. He often gets an attack when he’s stressed. And it’s due to over-vaccination at the shelter before I adopted him.

Homeopathic vets know that reverse sneezing usually stems from rabies over-vaccination.  Rabies vaccinosis often causes rabies-like symptoms. 

Rabid animals can experience jerky breathing or throat spasms.  In a dog with rabies vaccinosis it shows up as reverse sneezing.  It’s quite common in toy breeds as well as brachycephalic dogs … but other breeds do it too. 

For reverse sneezing it’s best to consult a homeopathic vet. He’ll analyze your dog’s symptoms and prescribe an appropriate constitutional remedy. 

In this article, homeopathic veterinarian Dr Ronna Kabler explains rabies miasm. She mentions some remedies homeopaths use to treat rabies vaccinosis symptoms in dogs. You can find a homeopathic vet at the Academy of Veterinary Homeopathy. Most will do phone consults … so they don’t have to be local. 

My dog’s reverse sneezing has improved with homeopathic treatment. He still does it once in a while, but homeopathy has helped his vaccinosis symptoms.

Acute Vaccine Reactions

One last thing. I mentioned earlier that your vet might suggest giving Benadryl before vaccination. This usually happens if your dog’s had an acute vaccine reaction in the past. 

By acute, I mean reactions that happen fast … within the first hours or days after vaccination. This type of reaction can be serious. It might be facial swelling or fever … which are unpleasant but manageable.

But it could be anaphylactic shock or even death.I’m not going to recommend a natural remedy for this. Yes, there are homeopathic remedies that can help with vaccine reactions

But the real solution is: don’t take the risk. If your dog’s ever had a vaccine reaction before, there’s a higher chance it’ll happen again. The answer to this problem is not “give Benadryl.” And it’s not to give this or that remedy to try to prevent the reaction. 

The answer is:  DO NOT vaccinate your dog again! Don’t let your vet do it. Find a different vet if you have to. 

And try not to give your dog Benadryl, now that you know about some natural options!

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